Several aspects of RNA synthesis and processing in eukaryotes are distinctly different from their counterparts in prokaryotes. Regulating the rate of transcription. The spliceosomal splicing cycle. Gene control regions Start site. In mature neurons , certain mRNA are transported from the soma to dendrites. A schematic view of the differences in the splicing mechanism of group I, group II, and spliceosome-dependent introns is shown in Figure
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Death of a dogma: eukaryotic mRNAs can code for more than one protein
Eukaryotic pre-mRNA processing
Diagram of alternative splicing. This concept assumes that ribosomes translate one ORF only, generally the longest one, and produce one protein. If this site is altered, an abnormally long and unstable mRNA construct will be formed.
AltSLC35A4 60 , 62 , , Splicing is required in eukaryotes to generate mature coding RNAs out of precursor RNAs which still contain noncoding regions Introns , they need to be removed to produce the correct protein. This article has been cited by other articles in PMC. The single CDS concept mainly stems from the canonical cap dependent scanning mechanism model for the selection of translation initiation sites in eukaryotic mRNAs. Proteins translated from altORFs have a different amino acid sequence and are not isoforms of the annotated proteins.